RECENT PUBLICATIONS (2006-2016)

(For more recent see PubMed link below)

Shimon Schuldiner in PubMed

  • Yaffe D, Vergara-Jaque A, Forrest LR, & Schuldiner S (2016) Emulating proton-induced conformational changes in the vesicular monoamine transporter VMAT2 by mutagenesis. Proc Natl Acad Sci U S A 113:E7390-E7398.

  • Shuster Y, Steiner-Mordoch S, Alon Cudkowicz N, Schuldiner S (2016) A Transporter Interactome Is Essential for the Acquisition of Antimicrobial Resistance to Antibiotics. PLoS ONE 11 (4): e0152917. doi: 10.1371/journal.pone.0152917

  • Melchior D.L., Brill S., Wright,G.E. and Schuldiner S. (2015) A liposomal method for evaluation of inhibitors of H+-coupled multidrug transporters." J Pharmacol Toxicol Methods 77: 53-57. PMID: 26463179

  • Brill, S., Sade-Falk, O., Elbaz-Alon, Y. and Schuldiner, S. (2015) Specificity determinants in small multidrug transporters. J Mol Biol 427: 468-477. PMID: 25479374

  • Yaffe D, Vergara-Jaque A, Shuster Y, Listov D, Meena S, Singh SK, Forrest, L. R., and Schuldiner, S. (2014). Functionally Important Carboxyls in a Bacterial Homologue of the Vesicular Monoamine Transporter (VMAT). J Biol Chem. 289:34229-34240. PMID: 25336661

  • Schuldiner S. (2014) Competition as a Way of Life for H-Coupled Antiporters. J Mol Biol. 426:2539-46. PMID: 24862284

  • Schuldiner S. What Can a Living Fossil Tell Us About Evolution and Mechanism of Ion-Coupled Transporters: The Story of Small Multidrug Transporters. In: Krämer R, Ziegler C, editors. Membrane Transport Mechanism: Springer Berlin Heidelberg; 2014. p. 233-248.

  • Nasie I, Steiner-Mordoch S, & Schuldiner S (2013) Topology determination of untagged membrane proteins. Methods Mol Biol 1033:121-130. PMID: 23996174

  • Ugolev Y, Segal T, Yaffe D, Gros Y, & Schuldiner S (2013) Identification of Conformationally Sensitive Residues Essential for Inhibition of Vesicular Monoamine Transport by the Noncompetitive Inhibitor-Tetrabenazine. J Biol Chem. 288:32160-32171 PMID: 24062308

  • Yaffe, D., Radestock, S., Shuster, Y., Forrest, L. R., and Schuldiner, S. (2013) Identification of molecular hinge points mediating alternating access in the vesicular monoamine transporter VMAT2. Proc Natl Acad Sci U S A 110, E1332-1341. PMID: 23530208

  • Nasie I, Steiner-Mordoch S, & Schuldiner S (2012) New Substrates on the Block: Clinically Relevant Resistances for EmrE and Homologues. J Bacteriol 194:6766-6770. PMID: 23042996.

  • Brill, S., Sade-Falk O., Schuldiner S. (2012). "Transforming a drug/H+ antiporter into a polyamine importer by a single mutation." Proc Natl Acad Sci U S A 109: 16894-16899. PMID: 23035252.

  • Schuldiner, S. (2012). "Undecided membrane proteins insert in random topologies. Up, down and sideways: it does not really matter." Trends Biochem Sci 37: 215-219. PMID: 22444835. 

  • Elbaz, Y. Danieli, T., Kanner, B.I. and Schuldiner, S. Expression of neurotransmitter transporters for structural and biochemical studies. Protein Expr Purif 73 (2010) 152-160. 

  • Nasie, I. Steiner-Mordoch, S., Gold, A. and Schuldiner, S. Topologically random insertion of EmrE supports a pathway for evolution of inverted repeats in ion-coupled transporters. J Biol Chem 285 (2010) 15234-15244. 

  • Gros, Y. and Schuldiner, S.  (2010) Directed evolution reveals hidden properties of VMAT, a neurotransmitter transporter. J. Biol. Chem. 285, 5076-5084. 

  • Miller, D., Charalambous, K., Rotem, D., Schuldiner, S., Curnow, P. & Booth, P. J. (2009). In vitro Unfolding and Refolding of the Small Multidrug Transporter EmrE. J Mol Biol. 393, 815-832.

  • Tal, N. and Schuldiner, S. (2009) A coordinated network of transporters with overlapping specificities provides a robust survival strategy Proc Natl Acad Sci U S A 106, 9051-9056. 

  • Schuldiner, S., (2009) EmrE, a model for studying evolution and mechanism of ion-coupled transporters. Biochim Biophy Acta 1794, 748-762. PDF

  • Elbaz Y, Salomon T, Schuldiner S (2008) Identification of a glycine motif required for packing in EmrE, a multidrug transporter from Escherichia coli. J Biol Chem 283: 12276-12283.

  • Adam Y, Edwards RH, Schuldiner S (2008) Expression and function of the rat vesicular monoamine transporter 2. Am J Physiol Cell Physiol 294: 1004-1011.

  • Steiner-Mordoch, S., Soskine, M., Solomon, D., Rotem, D., Gold, A., Yechieli, M., Adam, Y. and Schuldiner, S. (2008) Parallel Topology of Genetically Fused EmrE Homodimers. EMBO J., 27, 17-26. 

  • Agarwal V, Fink U, Schuldiner S, Reif B. (2007) MAS solid-state NMR studies on the multidrug transporter EmrE. Biochim Biophys Acta. 1768, 3036-43. 

  • Elbaz, Y. and Schuldiner, S. (2007) Drug Transport in Living Systems, in Begley, T.P. (Ed.) Wiley Encyclopedia of Chemical Biology. John Wiley & Sons, Inc. 

  • Adam, Y., Tayer, N., Rotem, D., Schreiber, G., and Schuldiner, S. (2007) The Fast Release of Sticky Protons: Kinetics of Substrate Binding and Proton Release in a Multidrug Transporter. Proc. Natl. Acad. Sci. USA,104, 17989-17994. 

  • Schuldiner, S. (2007) Controversy over EmrE structure. Science, 317:748-751 (letter). 

  • Schuldiner, S. 2007. When biochemistry meets structural biology: the cautionary tale of EmrE. Trends in Biochemical Sciences 32:252-258 

  • Soskine, M., Mark, S., Tayer, N., Mizrachi, R. and Schuldiner S. (2006) On parallel and antiparallel topology of an homodimeric multidrug transporter J. Biol. Chem. 281: 36205-36212. 

  • Schuldiner, S. (2006) Structural biology: the ins and outs of drug transport. Nature 443:156-157. 

  • Rotem, D., Steiner-Mordoch, S. and Schuldiner, S. (2006) Identification of tyrosine residues critical for the function of an ion-coupled multidrug transporter. J Biol Chem 281:18715-18722. 
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